![]() But new research has now proved this assumption wrong. There are several other places to look for the missing burden of risk, and one surprising possible source has recently emerged-an idea that overturns a fundamental tenet of biology and has many researchers excited about a completely new avenue of inquiry.Īccepted dogma holds that-although every cell in the body contains its own DNA-the genetic instructions in each cell nucleus are identical. More common mutations confer only small risks (although those risks become more significant when calculated across an entire population). Much frustration stems from the realization that the key mutations elevating disease risk tend to be rare because they are less likely to be passed on to offspring. Even the most important genetic risk factors identified for autism, for example, may account for only a few percent of all cases. But the genes singled out so far have provided only sketchy clues. The past few decades have seen intensive efforts to find the genetic roots of neurological disorders, from schizophrenia to autism. ![]()
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